Optimization of gene set annotations via entropy minimization over variable clusters (EMVC)
نویسندگان
چکیده
منابع مشابه
Optimization of gene set annotations via entropy minimization over variable clusters (EMVC)
MOTIVATION Gene set enrichment has become a critical tool for interpreting the results of high-throughput genomic experiments. Inconsistent annotation quality and lack of annotation specificity, however, limit the statistical power of enrichment methods and make it difficult to replicate enrichment results across biologically similar datasets. RESULTS We propose a novel algorithm for optimizi...
متن کاملTechnical Report: Adjudication of Coreference Annotations via Answer Set Optimization
We describe the first automatic approach for merging coreference annotations obtained from multiple annotators into a single gold standard. This merging is subject to certain linguistic hard constraints and optimization criteria that prefer solutions with minimal divergence from annotators. The representation involves an equivalence relation over a large number of elements. We use Answer Set Pr...
متن کاملPattern discovery via entropy minimization
We propose a framework for learning hiddenvariable models by optimizing entropies, in which entropy minimization, posterior maximization, and free energy minimization are all equivalent. Solutions for the maximum a posteriori (MAP) estimator yield powerful learning algorithms that combine all the charms of expectation-maximization and deterministic annealing. Contained as special cases are the ...
متن کاملOptimization of Double Pipe Fin-pin Heat Exchanger Using Entropy Generation Minimization
In the current work optimization of double pipe fin-pin heat exchanger has been studied. The effective parameters those are controlling the heat exchanger performance are divided in two categories; geometrical and operating conditions. Using the Brent’s optimization algorithm and handling the thermodynamically design concept, one can minimize entropy generation in different length of heat excha...
متن کاملOn Optimization 14 : 732 - - 742 , 2004 Minimization of Error Functionals over Variable - Basis Functions
There is investigated generalized Tychonov well-posedness of the problem of minimization of error functionals over admissible sets formed by variable-basis functions, which include neural networks. For admissible sets formed by variable-basis functions of increasing complexity, rates of decrease of infima of error functionals are estimated. There are derived upper bounds on such rates that do n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2014
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btu110